Adrenal steroids suppress granule cell death in the developing dentate gyrus through an NMDA receptor-dependent mechanism.
نویسندگان
چکیده
Treatment with the NMDA receptor antagonist MK-801 prevented the adrenal steroid-induced suppression of cell death, determined by both morphological identification of pyknotic cells and TUNEL staining, in the dentate gyrus in rat pups. This finding suggests that adrenal steroids naturally promote granule cell survival via NMDA receptor activation.
منابع مشابه
Stress inhibits the proliferation of granule cell precursors in the developing dentate gyrus.
The granule cell population of the dentate gyrus is produced predominantly during the postnatal period in rats. Previous studies have shown that experimental increases in the levels of adrenal steroids suppress the proliferation of granule cell precursors during the first postnatal week, the time of maximal neurogenesis in the dentate gyrus. These findings raise the possibility that stressful e...
متن کاملActivation of the type 2 adrenal steroid receptor can rescue granule cells from death during development.
To determine whether activation of the type 2 adrenal steroid receptor affects granule cell death in the developing dentate gyrus, we treated rat pups with the type 2 receptor agonist RU28362 and examined degenerating cells using terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick end labeling (TUNEL) and Nissl staining. RU28362 administration decreased the numbers of degenerating gr...
متن کاملAdult neurogenesis is regulated by adrenal steroids in the dentate gyrus.
The dentate gyrus of the rat produces new granule neurons well into adulthood. In the adult, newly born granule neurons migrate from the hilus to the granule cell layer, receive synaptic input, extend axons into the mossy fiber pathway, and express a neuronal marker. No previous studies have identified factors that regulate neuronal birth in the adult dentate gyrus. In order to determine whethe...
متن کاملAdrenal steroids regulate postnatal development of the rat dentate gyrus: I. Effects of glucocorticoids on cell death.
The rat dentate gyrus undergoes a period of naturally occurring cell death during the first postnatal week. In the adult rat, removal of circulating adrenal steroids by adrenalectomy is followed by massive death in the granule cell layer, thus raising the possibility that developmental cell death results from low levels of these hormones. Interestingly, the first two postnatal weeks of life in ...
متن کاملPii: S0306-4522(97)00303-5
–Adrenal steroids and N-methyl--aspartate receptor activation have both been shown to regulate the rate of proliferation of granule neuron progenitor cells in the dentate gyrus of adult rats [Cameron H. A. and Gould E. (1994) Neuroscience 61, 203–209; Cameron H. A. et al. (1995) J. Neurosci. 15, 4687–4692]. Parallels between the actions of these two factors suggest that they may regulate cell ...
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عنوان ژورنال:
- Brain research. Developmental brain research
دوره 103 1 شماره
صفحات -
تاریخ انتشار 1997